Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review

Autores

  • Júlia Niehues da Cruz Instituto Dante Pazzanese de Cardiologia
  • Débora Delwing Dal Magro Universidade Regional de Blumenau
  • Daniela Delwing de Lima Universidade da Região de Joinville
  • José Geraldo Pereira da Cruz Universidade Regional de Blumenau

DOI:

https://doi.org/10.1590/s2175-97902017000116102

Palavras-chave:

Anxiolytic effects, Membrane/lipid rafts, N-methyl-D-aspartate, Simvastatin.

Resumo

Membrane/lipid rafts (MLRs) are plasmalemmal microdomains that are essential for neuronal signaling and synaptic development/stabilization. Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (statins) can disable the N-methyl-D-aspartate (NMDA) receptor through disruption of MLRs and, in turn, decrease NMDA-mediated anxiety. This hypothesis will contribute to understanding the critical roles of simvastatin in treating anxiety via the NMDA receptor.

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Publicado

2017-01-01

Edição

v. 53 n. 1 (2017)

Seção

Revisão

Licença

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

Como Citar

Simvastatin treatment reduces the cholesterol content of membrane/lipid rafts, implicating the N -methyl-D-aspartate receptor in anxiety: a literature review. (2017). Brazilian Journal of Pharmaceutical Sciences, 53(1), e16102-. https://doi.org/10.1590/s2175-97902017000116102