Radiolabeling of cidofovir with technetium-99m and biodistribution studies

Autores

  • Raquel Gregorio Arribada Federal University of Minas Gerais, Faculty of Pharmacy, Department of Pharmaceutical Products https://orcid.org/0000-0003-0442-6730
  • Nara Caroline Pereira Federal University of Minas Gerais, Faculty of Pharmacy, Department of Clinical and Toxicological Analyses
  • Valbert Nascimento Cardoso Federal University of Minas Gerais, Faculty of Pharmacy, Department of Clinical and Toxicological Analyses
  • Armando da Silva Cunha Júnior Federal University of Minas Gerais, Faculty of Pharmacy, Department of Pharmaceutical Products
  • André Luís Branco de Barros Federal University of Minas Gerais, Faculty of Pharmacy, Department of Clinical and Toxicological Analyses

DOI:

https://doi.org/10.1590/s2175-97902019000418511

Palavras-chave:

Cidofovir, Radiotracer, Technetium-99m, Biodistribution, Scintigraphic imaging

Resumo

Radiolabeling cidofovir with technetium-99m (99mTc-CDV) is an innovative procedure that enables real-time monitoring of the drug. Essays were performed in vitro, showing high radiolabel stability within 24 h. Blood clearance, biodistribution studies, and scintigraphic images were performed in healthy mice in order to evaluate the profile of the drug in vivo. 99mTc-CDV showed biphasic blood circulation time and significant kidney uptake, indicating that 99mTc-CDV is preferentially eliminated by the renal route. Bones also showed important uptake throughout the experiment. In summary, cidofovir was successfully labeled with technetium-99m and might be used in further studies to track the drug.

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Publicado

2020-12-09

Edição

v. 56 (2020)

Seção

Article

Licença

Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

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Como Citar

Radiolabeling of cidofovir with technetium-99m and biodistribution studies. (2020). Brazilian Journal of Pharmaceutical Sciences, 56, e18511 . https://doi.org/10.1590/s2175-97902019000418511