Naringin is a promising natural compound for therapy of iron-overload disorders
DOI:
https://doi.org/10.1590/s2175-97902022e19409Keywords:
Iron chelation activity, Naringin, Deferoxamine, Iron overloaded miceAbstract
Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl’s staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders.
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References
Andrews NC. Disorders of Iron Metabolism. N Engl J Med. 1999;341(26):1986-1995.
Badria FA, Ibrahim AS, Badria AF, Elmarakby AA. Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats. PLoS One. 2015;10(7):e0134156.
Basu T, Panja S, Shendge AK, Das A, Mandal N. A natural antioxidant, tannic acid mitigates iron‐overload induced hepatotoxicity in Swiss albino mice through ROS regulation. Environ Toxicol. 2018;33(5):603-618.
Cavia‐Saiz M, Busto MD, Pilar‐Izquierdo MC, Ortega N, Perez‐Mateos M, Muñiz P. Antioxidant properties, radical scavenging activity and biomolecule protection capacity of flavonoid naringenin and its glycoside naringin: a comparative study. J Sci Food Agric. 2010;90(7):1238-1244.
Chaudhuri D, Ghate NB, Panja S, Basu T, Shendge AK, Mandal N. Glycoside rich fraction from Spondias pinnata bark ameliorate iron overload induced oxidative stress and hepatic damage in Swiss albino mice. BMC Complement Altern Med. 2016;16(1):262.
Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women: The Camden study. Diabetes Care. 2006;29(5):1077-1082.
Chinonyelum AN, Uwadiegwu AP, Nwachukwu OC, Emmanuel O. Evaluation of hepatoprotective activity of Colocasia esculenta (L. Schott) leaves on thioacetamide-induced hepatotoxicity in rats. Pak J Pharm Sci. 2015;28(6 Suppl):2237-2241.
Ebrahimzadeh MA, Khalili M, Azadbakht M, Azadbakht M. Salvia Virgata Jacq. and Silibum Marianum L. Gaertn Display Significant Iron-Chelating ActivityInt. J Pharm Sci Res. 2016;7(9):3756.
El-Shanshory M, Hablas NM, Aboonq MS, Fakhreldin AR, Attia M, Arafa W et al. Nigella sativa improves anemia, enhances immunity and relieves iron overload-induced oxidative stress as a novel promising treatment in children having beta-thalassemia major. J Herb Med. 2018;100245.
Eslami S, Ebrahimzadeh MA, Biparva P. Green synthesis of safe zero valent iron nanoparticles by Myrtus communis leaf extract as an effective agent for reducing excessive iron in iron-overloaded mice, a thalassemia model. RSC Advances. 2018;8(46):26144-26155.
Farrar JE, Nater M, Caywood E, McDevitt MA, Kowalski J, Takemoto CM et al. Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood. 2008;112(5):1582-1592.
Gilbert DL, Colton CA (1999) Reactive oxygen species in biological systems: an interdisciplinary approach. Springer. doi:10.1016/S0144-8617(01)00197-7
» https://doi.org/10.1016/S0144-8617(01)00197-7
Grady RW, Galanello R, Randolph RE, Kleinert DA, Dessi C, Giardina PJ. Toward optimizing the use of deferasirox: potential benefits of combined use with deferoxamine. Haematologica. 2013;98(1):129-135.
Grazul M, Budzisz E. Biological activity of metal ions complexes of chromones, coumarins and flavones. Coord Chem Rev. 2009;253(21-22):2588-2598.
Jagetia GC, Reddy TK. Modulation of radiation-induced alteration in the antioxidant status of mice by naringin. Life Sci. 2005;77(7):780-794.
Jagetia GC, Reddy TK. Alleviation of iron induced oxidative stress by the grape fruit flavanone naringin in vitro. Chem Biol Interact. 2011;190(2):121-128.
Khalili M, Ebrahimzadeh MA, Kosaryan M. In Vivo Iron-Chelating Activity and Phenolic Profiles of the Angel's Wings Mushroom, Pleurotus porrigens (Higher Basidiomycetes). Int J Med Mushrooms. 2015a;17(9):847-856.
Khalili M, Ebrahimzadeh MA, Kosaryan M, Abbasi A, Azadbakht M. Iron chelation and liver disease healing activity of edible mushroom (Cantharellus cibarius), in vitro and in vivo assays. RSC Advances . 2015b;5(7):4804-4810.
Kontoghiorghes GJ. Deferasirox: uncertain future following renal failure fatalities, agranulocytosis and other toxicities. Expert Opin Drug Saf. 2007;6(3):235-239.
Lai ME, Grady RW, Vacquer S, Pepe A, Carta MP, Bina P et al. Increased survival and reversion of iron-induced cardiac disease in patients with thalassemia major receiving intensive combined chelation therapy as compared to desferoxamine alone. Blood Cells Mol Dis. 2010;45(2):136-139.
Mira L, Tereza Fernandez M, Santos M, Rocha R, Helena Florêncio M, Jennings KR. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radic Res. 2002;36(11):1199-1208.
Mladěnka P, Macáková K, Filipský T, Zatloukalová L, Jahodář L, Bovicelli P et al. In vitro analysis of iron chelating activity of flavonoids. J Inorg Biochem. 2011;105(5):693-701.
Pari L, Prasath A. Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. Chem Biol Interact . 2008;173(2):77-83.
Porter JB. Optimizing iron chelation strategies in β-thalassaemia major. Blood Rev. 2009;23 Supplement 1:S3-S7.
Reddy ACP, Lokesh B. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology. 1996;107(1):39-45.
Sarkar R, Hazra B, Mandal N. Reducing power and iron chelating property of Terminalia chebula (Retz.) alleviates iron induced liver toxicity in mice. BMC Complement Altern Med . 2012;12(1):1-10.
van Acker SA, van Balen GP, van den Berg DJ, Bast A, van der Vijgh WJ. Influence of iron chelation on the antioxidant activity of flavonoids. Biochem Pharmacol. 1998;56(8):935-943.
Verdan AM, Wang HC, García CR, Henry WP, Brumaghim JL. Iron binding of 3-hydroxychromone, 5-hydroxychromone, and sulfonated morin: implications for the antioxidant activity of flavonols with competing metal binding sites. J Inorg Biochem . 2011;105(10):1314-1322.
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Golestan University of Medical Sciences
Grant numbers 951217302
