Evaluation of copaiba oil as enhancer of ibuprofen skin permeation

Rodrigo Lupatini; Richard Grazul; Ademar Alves da Silva Filho; Jorge Willian Leandro Nascimento

doi:10.1590/s2175-97902022e19548

Authors

Rodrigo Lupatini Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
Richard Grazul Department of Chemistry, Institute of Exact Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil
Ademar Alves da Silva Filho Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil https://orcid.org/0000-0002-9096-1336
Jorge Willian Leandro Nascimento Department of Pharmacology, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil https://orcid.org/0000-0002-0334-0217

DOI:

https://doi.org/10.1590/s2175-97902022e19548%20

Keywords:

Copaiba oil, Terpenes, Ibuprofen, Penetration enhancer, Pig skin

Abstract

The administration of medications on the skin through transcutaneous routes is a practice that has been used by mankind for millennia. Some studies have been reporting the use of terpenes and natural oils rich in terpenes as an enhancer of cutaneous penetration. Copaiba oil, due to its rich content of terpenes, presents itself as a great choice of penetration enhancer for drugs administered on the skin. In this study, we developed two cream formulations containing 5% of ibuprofen (IBU) and copaiba oil: IBCO5 and IBCO10 with 5% and 10% of copaiba oil respectively. Ex vivo cutaneous penetration/permeation studies of IBU were performed using pig ear skin as biological membrane in the Franz-type diffusion cells. The steady-state flux of IBU samples, IBCO5 (35.72 ± 6.35) and IBCO10 (29.78 ± 2.41) were significantly higher when compared with control without copaiba oil (10.32 ±1.52) and with a commercial product (14.44 ± 2.39). In the penetration analysis, the amount of IBU found in the samples IBCO5 and IBCO10 was markedly higher in the dermis than epidermis. Our results showed that copaiba oil possesses attracting properties in promoting skin penetration and permeation of IBU when added into cream formulations.

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Evaluation of copaiba oil as enhancer of ibuprofen skin permeation

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