Persea americana Mill.

Evaluation of cytogenotoxicity and phytochemical prospection of leaf extracts

Autores

  • Danilo Giovanni Narciso Pastura Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological
  • Jaqueline das Virgens Sousa Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Mayara Christine Silva Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health,
  • Aline Ferreira Matos Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Hataânderson Luiz Cabral dos Santos Organic Chemistry Department, Laboratory of Medicinal Chemistry and Honey Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil
  • Gabriela Lopes Pereira Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Ellen Borges da Rocha Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Raphael Santiago Alves Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Leonardo de Oliveira Bastos Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Lucas de Oliveira Pires Organic Chemistry Department, Laboratory of Medicinal Chemistry and Honey Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil
  • Rosane Nora Castro Organic Chemistry Department, Laboratory of Medicinal Chemistry and Honey Chemistry, Institute of Chemistry, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil
  • Helcio Resende Borba Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil,
  • Viviane Moreira de Lima Department of Animal Biology, Laboratory of Genotoxic Activity of Plants, Institute of Biological Sciences and Health, Federal Rural University of Rio de Janeiro, Seropédica, RJ, Brazil, https://orcid.org/0000-0001-7930-8312

DOI:

https://doi.org/10.1590/s2175-97902022e19261

Palavras-chave:

Persea americana, Allium cepa, Micronucleus, Genotoxicity, Cytotoxicity, Phytochemical

Resumo

Persea americana Mill., belonging to the family Lauraceae, is noteworthy for the large amount of ethnopharmacological information in its regard, attributing to it many and varied medicinal properties. The tea and alcoholic extracts made from its leaves are used in folk medicine to treat various ailments. This study was designed to analyze the cytogenotoxicity and underlying chemistry of aqueous and hydroalcoholic extracts of avocado leaves, using the Allium cepa and micronucleus tests. The results obtained by applying the experimental models demonstrate that the extracts did not have a genotoxic effect at any of the concentrations analyzed, and even demonstrated a certain protective effect, possibly due to the presence of flavonoids and phenols, both of which are antioxidant substances. However, the extracts did present a cytotoxic effect. There were numerous karyorrhectic cells and those with nuclear alterations related to cell death. At the highest concentrations, it was possible to observe cytoplasmic alterations and binucleated cells. The extracts also caused a significant reduction in the number of cells undergoing division. These effects can be a response to the phytochemical agents present in the extracts. The results suggest that the extracts contain bioactive components that deserve further studies related to cancer therapies.

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Publicado

2022-04-20

Edição

v. 58 (2022)

Seção

Original Article

Licença

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

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Como Citar

Persea americana Mill.: Evaluation of cytogenotoxicity and phytochemical prospection of leaf extracts. (2022). Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e19261