Validation of the Brazilian version of the hepatitis B quality of life evaluation instrument - HBQOL, and its application to patients with chronic hepatitis B in Cascavel - PR
DOI:
https://doi.org/10.1590/s2175-97902022e191111%20Palavras-chave:
Quality of life, Chronic hepatitis B, TherapeuticsResumo
The objective of this study is to validate the specific questionnaire for Hepatitis B HBQOL (Hepatitis B Quality of Life Instrument, version 1.0) for the Brazilian version, in addition to testing its applicability in patients with hepatitis B under treatment and comparing the quality of life between patients using first-line drugs (tenofovir and entecavir). For the validation, the back-translation technique was used in a sample of 47 patients. Factor analysis was performed between the items in each domain of the questionnaire and the internal consistency was calculated using Cronbach's α coefficient. In assessing the applicability of the validated questionnaire, interviews were carried out with 124 patients. Sociodemographic and treatment data were collected to characterize the sample and perform correlation analyzes. The results demonstrate that the Brazilian version of the questionnaire was successfully validated. In the analysis carried out among the 124 patients, the domains psychological well-being and stigma obtained the highest scores in quality of life and the lowest level of education conferred better results in these two domains. The comparison between tenofovir and entecavir showed no significant difference in patients' quality of life. The use of this validated instrument can make therapeutic decisions more rational.
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Almeida AM, DaSilva AL, Brandão MR, Cherchiglia ML, Andrade EIG, DeOliveira GLA, et al. Custo-efetividade dos análogos de nucleosídeos/nucleotídeos para hepatite crônica B. Rev Saúde Pública. 2012;46(6):942-949.
Abdo AA. Health-related quality of life os Saudi Hepatitis B and C patients. Ann Saudi Med. 2012;32(4):397-403.
Brasil. Instituto Brasileiro de Geografia e Estatística. Pesquisa Nacional por Amostra de Domicílios Contínua - PNAD Contínua. Educação: 2019. [Internet]. IBGE, 2019. Available in:https://www.ibge.gov.br/estatisticas/sociais/educacao/17270-pnad continua.html?=&t=publicacoes
» https://www.ibge.gov.br/estatisticas/sociais/educacao/17270-pnad continua.html?=&t=publicacoes
Brasil. Instituto Brasileiro de Geografia e Estatística. Síntese de Indicadores Sociais: Uma Análise das Condições de Vida da População Brasileira. [Internet]. IBGE, 2014a. Available in: https://www.ibge.gov.br/estatisticas/multidominio/condicoes-de-vida-desigualdade-e-pobreza/9221-sintese-de-indicadores-sociais.html?edicao=17068&t=publicacoes
Brasil. Ministério da Saúde. Blog da saúde. 57,4 milhões de brasileiros têm pelo menos uma doença crônica. [Internet]. Brasília (DF): Ministério da Saúde, 2014b. Available in: http://www.blog.saude.gov.br/index.php/34861-57-4-milhoes-de-brasileiros-tem-pelo-menos-uma-doenca-cronica
Buti M. HBeAg-positive chronic hepatitis B: Why do I treat my patients with nucleos(t)ide analogs? Liver Int. 2014;34(1):108-111.
Chao DC, Hu KQ. Update on rescue therapies in patients with lamivudine-resistant chronic hepatitis B. Drug Des Devel Ther. 2013;7:777-788.
Chao J, Song L, Zhang H, Zhu L, Tian L, Jin H, et al. Effects of comprehensive intervention on health-related quality of life in patients with chronic hepatitis B in China. BMC Health Serv Res. 2013;13(386):1-9.
Che YH, You J, Chongsuvivatwong V, Li L, Spriplung H, Yan YZ, et al. Dynamics and Liver Disease Specifi Aspects of Quality of Life Among Patients with Chronic Liver Disease in Yunnan, China. Asian Pac J Cancer Prev. 2014;15(12):4765-4771.
Cholongitas E, Tziomalos K, Pipili C. Management of patients with hepatitis B in special populations. World J Gastroenterol. 2015;21(6):1738-1748.
Dan AA, Kallman JB, Srivastava R, Younoszai Z, Kim A, Younossi ZM. Impact of chronic liver disease and cirrhosis on health utilities using SF-6D and the health utility index. Liver transpl. 2008;14(3):321-326.
DeFrancesco MA, Gargiulo F, Spinetti A, Zaltron S, Giagulli C, Caccuri F. Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine. New Microbiol. 2015;3(1):29-37.
Hair JF, Tatham RL, Anderson RE, Black W. Multivariate Data Analysis. 5th ed. New Jersey: Prentice-Hall; 1998.
Haq H, Hassali A, Shafie AA, Saleem F, Farooqui M, Aljadhey H, et al. Association between Hepatitis B-Related nowledge and Health-Related Quality of Life. Trop J Pharm Res. 2014;13(7):1163-1168.
Kim SJ, Han KT, Lee SY, Park EC. Quality of life correlation with socioeconomic status in Korean hepatitis-B patients: a cross sectional study. Health Qual Life Outcomes. 2015;13(55):1-12.
Lam ETP, Lam CLK, Lai CL, Yuen MF, Fong DYY, So TMK. Health-related quality of life of Southern Chinese with chronic hepatitis B infection. Health Qual. Life Outcomes. 2009;7(52):1-10.
Marcelin P, Lau GKK, Zeuzem S, Healthcote EJ, Pockros PJ, Reddy KR, et al. Comparing the safety, tolerability and quality of life in patients with chronic hepatitis B vs chronic hepatitis C treated with peginterferonalpha-2a. Liver Int . 2008;28(4):477-485.
Mutimer DJ, Oo YH. Hepatitis B. Med. 2011;39(9):545-549.
Poorkaveh A, Modabbernia A, Ashrafi M, Taslimi S, Karami M, Dalir M, et al. Validity, Reliability and Factor Structure of Hepatitis B Quality of Life Questionnaire Version 1.0: Findings in a Large Sample of 320 patients. Arch Iran med. 2012;15(5):290-296.
Qiao CX, Zhai XF, Ling CQ, Lang QB, Dong HJ, Liu Q, et al. Health-related quality of life evaluated by tumor node metastasis staging system in patients with hepatocellular carcinoma. World J Gastroenterol . 2012;18(21):2689-2694.
R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Viena, 2015. Available in: http://www.r-project.org/
Saffari M, Alavian SM, Naderi MK, Pakpour AH, Alzaben F, Koenig HG. Cross-cultural adaptation and psychometric assessment of the liver disease symptom index 2.0 to measure health-related quality of life among Iranian patients with chronic hepatitis B. J Transcult Nurs Memphis. 2015:1-13.
Spiegel BMR, Bolus R, Han S, Tong M, Esrailian E, Talley J, et al. Development and validation of a disease-targeted quality of life instrument in chronic hepatitis B: The hepatitis B quality of life instrument, Version 1.0. Hepatology. 2007;46 (1):113-121.
Strauss E, Porto-ferreira FA, DeAlmeida Neto C, Teixeira MC. Altered quality of life in the early stages of chronic hepatitis C is due to the virus itself. Clin Res Hepatol Gastroenterol. 2014;38(1):40-45.
Trépo C, Chan HLY, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053-2063.
Zhuang G, Zhang M, Liu Y, Guo Y, Wu Q, Zhou K, et al. Significant impairment of health-related quality of life in mainland Chinese patients with chronic hepatitis B: a cross-sectional survey with pair-matched healthy controls. Health Qual Life Outcomes. 2014;12(101):1-9.
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