Impact of supplemental vitamins and natural honey for treatment of COVID-19
a review
DOI:
https://doi.org/10.1590/s2175-97902022e20607Keywords:
Vitamin C, Vitamin D, Natural Honey, Lung Damage, Antiviral EffectsAbstract
The main aim of the paper is to assess whether vitamin C, vitamin D, and natural honey can be administered in the course of the COVID-19 pandemic for promising in line methods with recent evidence. Both systematic literature and clinical trial identification were conducted by searching various databases. A total 58 articles and 29 clinical trials were selected wherein 11 for vitamin C, 16 for vitamin D, and 2 for natural honey were identified for analysis. The high doses of vitamin C (i.e. ‘200 mg/kg body weight/day, divided into 4 doses’) has been found to reduce COVID-19 lung damage, various flu infections. Additionally, the high doses of vitamin C can shorten around 7.8% stay in the intensive care unit. At the same time, vitamin D can effectively protect from lung injury and acute respiratory infections whereas vitamin D deficiency severely affects 75% of the institutionalized people (serum 25(OH) D < 25 nmol/L). Meanwhile, natural honey which contains proteins (0.1-0.4%); ash (0.2%); water (15-17%) has potential antiviral effects and the ability to improve immunity. Therefore, the administration of vitamins and honey is the promising evidence-based approach for reducing fatalities, saving lives, and bringing the COVID-19 pandemic to a rapid end. It is believed that the utilization of vitamin C, vitamin D, and natural honey with the current treatment may be effective in treating COVID-19-caused fatal complications such as pneumonia. Therefore, high-level clinical studies are required on COVID-19 to administrate the effects of vitamins and natural honey
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Abbas AC, Alwaeli AZ, Abbas EC, Mohamed A. Effect of honey consumed of COVID-19 patients over time and changes in concentrations levels of antioxidants and oxidative stress in the patients over time and compare with control group. Ann Romanian Soc Cell Biol. 2021;25(6):8961-74.
Abrishami A, Dalili N, Torbati PM, Asgari R, Arab-Ahmadi M, Behnam B, et al. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2021;60(4):2249-57.
Abu-Amer Y, Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell Immunol. 1993;151(2):356-68.
Adami S, Bertoldo F, Braga V, Fracassi E, Gatti D, Gandolini G, et al. 25-hydroxy vitamin D levels in healthy premenopausal women: association with bone turnover markers and bone mineral density. Bone. 2009;45(3):423-6.
Ahmed N, Araf Y, Ullah MA. Prospects of vitamin D in the treatment of COVID-19 patient and improving maternal and child health during pandemic. J Adv Biotechnol Exp Ther. 2021;4(2):133-48.
Ahmed S, Othman NH. Review of the medicinal effects of tualang honey and a comparison with manuka honey. Malays J Med Sci. 2013;20(3):6-13.
Ali I, Alharbi OM. COVID-19: Disease, management, treatment, and social impact. Sci Total Environ. 2020;728:138861.
Al-Waili NS. Topical honey application vs. acyclovir for the treatment of recurrent herpes simplex lesions. Med Sci Monit. 2004;10(8):MT94-8.
Awad OG, Hamad AM. Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial. Am J Otolaryngol. 2018;39(6):759-63.
Bhagavathula AS, Aldhaleei WA, Rahmani J, Mahabadi MA, Bandari DK. Knowledge and Perceptions of COVID-19 Among Health Care Workers: Cross-Sectional Study. JMIR Public Health Surveill. 2020;6(2):e19160.
Braithwaite MC, Kumar P, Tyagi C, Tomar LK, Choonara YE, Pillay V. Vitamin D therapy and related metabolomics: is the calciferol dose and form the only requirements for successful clinical therapeutics? Med Hypotheses. 2013;81(4):656-63.
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, Chen H, et al. A new mechanism of vitamin C effects on A/FM/1/47 (H1N1) virus-induced pneumonia in restraint-stressed mice. Biomed Res Int. 2015;2015:675149.
Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211-36.
Cheng RZ. Can early and high intravenous dose of vitamin C prevent and treat coronavirus disease 2019 (COVID-19)? Med Drug Dev. 2020;5:100028.
Cui C, Xu P, Li G, Qiao Y, Han W, Geng C, et al. Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: role of renin- angiotensin system. Redox Biol. 2019;26:101295.
Elste V, Troesch B, Eggersdorfer M, Weber P. Emerging evidence on neutrophil motility supporting its usefulness to define vitamin C intake requirements. Nutrients . 2017;9(5):503.
El-Sayed SM, Almaramhy HH, Aljehani YT, Okashah AM, El-Anzi ME, AlHarbi MB, et al. TaibUVID for Minimizing COVID-19 Fatalities and Morbidity: An Evidence-based Approach for Better Outcomes (A Treatment Protocol). Am J Public Health. 2020;8(2):54-60.
EU Clinical Trials Register. [cited 2020 Jun 2]. Available from: Available from: https://www.clinicaltrialsregister.eu
» https://www.clinicaltrialsregister.eu
Eurosurveillance Editorial Team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Eurosurveillance. 2020;25(5):200131e.
Farjana M, Moni A, Sohag AA, Hasan A, Hannan MA, Hossain MG, et al. Repositioning vitamin C as a promising option to alleviate complications associated with COVID-19. Infect Chemother. 2020;52(4):461.
Fowler III AA, Kim C, Lepler L, Malhotra R, Debesa O, Natarajan R, et al. Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome. World J Crit Care Med. 2017;6(1):85-90.
Gao D, Xu M, Wang G, Lv J, Ma X, Guo Y, et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: A retrospective cohort study. Aging (Albany NY). 2021;13(5):7020-34.
Gruber-Bzura BM. Vitamin D and influenza-prevention or therapy? Int J Mol Sci. 2018;19(8):2419.
Güleşci N, Aygül İ. Beslenmede yer alan antioksidan ve fenolik madde içerikli çerezler. Gümüşhane Üni Sağlık Bilimleri Derg. 2016;5(1):109-29.
Hançer AT, Yilmaz P, Yilmaz M. New Coronavirus (2019- nCoV/COVID-19) and Vitamin C. Turk Klin Tip Bilimleri Derg. 2020;40(2):260-4.
Helming L, Böse J, Ehrchen J, Schiebe S, Frahm T, Geffers R, et al. 1α, 25-dihydroxyvitamin D3 is a potent suppressor of interferon γ-mediated macrophage activation. Blood. 2005;106(13):4351-8.
Hemilä H, Chalker E. Vitamin C can shorten the length of stay in the ICU: a meta-analysis. Nutr. 2019;11(4):708.
Hossain KS, Hossain MG, Moni A, Rahman MM, Rahman UH, Alam M, et al. Prospects of honey in fighting against COVID-19: pharmacological insights and therapeutic promises. Heliyon. 2020;6(12):e05798.
Ilie PC, Stefanescu S, Smith L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res. 2020;32:1195-8.
Information on Clinical Trials and Human Research Studies. [cited 2020 Jun 2]. Available from: Available from: https://clinicaltrials.gov
Kalediene L, Baz M, Liubaviciute A, Biziuleviciene G, Grabauskyte I, Bieliauskiene R, et al. Antiviral effect of honey extract Camelyn against SARS-CoV-2. J Adv Biotechnol Exp Ther . 2021;4(3):290-7.
Kim H, Jang M, Kim Y, Choi J, Jeon J, Kim J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/ H1N1 infection. J Pharm Pharmacol. 2016;68(3):406-20.
Koshiba T, Yasukawa K, Yanagi Y, Kawabata SI. Mitochondrial membrane potential is required for MAVS- mediated antiviral signaling. Sci Signal. 2011;4(158):ra7.
Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Curr Opin Pharmacol. 2006;6(3):271-6.
Kumar P, Kumar M, Bedi O, Gupta M, Kumar S, Jaiswal G, et al. Role of vitamins and minerals as immunity boosters in COVID-19. Inflammopharmacol. 2021;29:1001-16.
Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges. Int J Antimicrob Agents. 2020;55(3):105924.
Li J. Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis. Crit Care. 2018;22(1):258.
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;382(13):1199-1207.
Lips P, Cashman KD, Lamberg-Allardt C, Bischoff-Ferrari HA, Obermayer-Pietsch B, Bianchi ML, et al. Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society. Eur J Endocrinol. 2019;180(4):P23-54.
Liu Q, Gao Y, Ci X. Role od Nrf2 and its activators in respiratory diseases. Oxid Med Cell Longevity. 2019;2019:7090534.
MacLaughlin J, Holick MF. Aging decreases the capacity of human skin to produce vitamin D3. J Clin Invest. 1985;76(4):1536-8.
Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017;151(6):1229-38.
Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. Br Med J. 2017;356:i6583.
Münstedt K. Bee products and the treatment of blister-like lesions around the mouth, skin and genitalia caused by herpes viruses-A systematic review. Complement Ther Med. 2019;43:81-4.
Nabzdyk CS, Bittner EA. Vitamin C in the critically ill- indications and controversies. World J Crit Care Med . 2018;7(5):52-61.
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144:138-45.
Rabby MII. Current drugs with potential for treatment of COVID-19: A literature review. J Pharm Pharm Sci. 2020;23(1):58-64.
Rabby MII, Hossain F, Akhi IJ, Amin SS, Khan A. Understanding of General People about COVID-19: A Cross- Sectional Online Survey and Qualitative Presentation. Turk Klin Tip Bilimleri Derg . 2020;40(2):203-19.
Rabby MII, Hossain F. Study of ongoing registered clinical trials on COVID-19: a narrative review. Sao Paulo Med J. 2020;138(5):441-56.
Raftery T, A O’Morain C, O’Sullivan M. Vitamin D: new roles and therapeutic potential in inflammatory bowel disease. Curr Drug Metab. 2012;13(9):1294-302.
Ramanauskiene K, Stelmakiene A, Briedis V, Ivanauskas L, Jakštas V. The quantitative analysis of biologically active compounds in Lithuanian honey. Food Chem. 2012;132(3):1544-8.
Rao PV, Krishnan KT, Salleh N, Gan SH. Biological and therapeutic effects of honey produced by honey bees and stingless bees: a comparative review. Rev Bras Farmacogn. 2016;26(5):657-64.
Rogovskii VS. The linkage between inflammation and immune tolerance: interfering with inflammation in cancer. Curr Cancer Drug Targets. 2017;17(4):325-32.
Schievano E, Zuccato V, Finotello C, Vit P. Authenticity of Ecuadorian commercial honeys. Int J Biol Biomol Agric Food Biotechnol Eng. 2015;9(3):313-16.
Vit P, Deliza R, Pérez A. How a Huottuja (Piaroa) community perceives genuine and false honey from the Venezuelan Amazon, by free-choice profi le sensory method. Rev Bras Farmacogn . 2011;21(5):786-92.
Vit P, Vargas O, Valle FM. Meliponini biodiversity and medicinal uses of pot-honey from El Oro province in Ecuador. Emir J Food Agr. 2015;27(6):502-6.
Vit P, Uddin J, Zuccato V, Maza F, Schievano E. Entomological origin of honey discriminated by NMR chloroform extracts in Ecuadorian honey. Int J Biol Food Vet Agric Eng. 2015;9(5):437-40.
Watanabe K, Rahmasari R, Matsunaga A, Haruyama T, Kobayashi N. Anti-influenza viral effects of honey in vitro: potent high activity of manuka honey. Arch Med Res. 2014;45(5):359-65.
World Health Organization. Novel coronavirus (COVID-19) situation. [cited 2020 Jul 17]. Available from: Available from: https://experience. arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
» https://experience. arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd
Xudong X, Junzhu C, Xingxiang W, Furong Z, Yanrong L. Age-and gender-related difference of ACE2 expression in rat lung. Life Sci. 2006;78(19):2166-71.
Yaghoobi R, Kazerouni A. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: A review. Jundishapur J Nat Pharm Prod. 2013;8(3):100-4.
Yin Y, Wunderink RG. MERS, SARS and other coronaviruses as causes of pneumonia. Respirol. 2018;23(2):130-7.
Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, et al. Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care. 2021;11:1-12.
Zhao B, Ling Y, Li J, Peng Y, Huang J, Wang Y, et al. Beneficial aspects of high dose intravenous vitamin C on patients with COVID-19 pneumonia in severe condition: a retrospective case series study. Ann Palliat Med. 2021;10:1599-609.
Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, et al. Angiotensin- converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nat Commun. 2014;5(1):1-7.
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