Prevalence of Streptococcus agalactiae capsular types among pregnant women in Rio de Janeiro and the impact of a capsular based vaccine
DOI:
https://doi.org/10.1590/s2175-979020222e20633Palavras-chave:
Molecular Epidemiology, Pregnancy, Streptococcus Agalactiae, VaccineResumo
Streptococcus agalactiae (group B Streptococcus, GBS) remains one major neonatal pathogen, being maternal colonization a risk factor for infection development. Despite effective, the usage of antibiotics to prevent neonatal infections has limitations. The bacterial polysaccharide capsule is a virulence determinant, a target for vaccine directed to pregnant women, and also the most useful epidemiological marker of GBS infections. Capsular polysaccharides are diverse and disease severity varies according to the expressed type. Here, capsular typing of 124 GBS isolates recovered from pregnant women was determined by a multiplex PCR-based method. The most frequent types were Ia (33.0%), II (25.8%) and V (21.8%). Other types found were Ib (8.9%), III (8.9%) and IV (1.6%). While type Ia was prevalent during the whole period (2002-2018), fluctuations in distribution of other types, specially V, were observed over time. Capsular type III, traditionally associated with severe neonatal infections, was poorly detected. Distribution of maternal GBS capsular types in the metropolitan area of Rio de Janeiro, with prevalence of Ia and II, is quite different from other parts of the world. The knowledge about GBS capsular type distribution is essential to predict the theoretical impact of developing capsule-based vaccines in the local population
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ACOG Committee Opinion. Prevention of group B Streptococcal early-onset disease in newborns. Obstet Gynecol. 2020; 135(2):e51-72.
Botelho ACN, Oliveira JG, Damasco AP, Santos KTB, Ferreira AFM, Rocha GT, et al. Streptococcus agalactiae carriage among pregnant women living in Rio de Janeiro, Brazil, over a period of eight years. PLOS One. 2018;13(5):e0196925.
Brasil. Ministério da Saúde. Cadernos de Atenção Básica. Atenção ao Pré-Natal de Baixo Risco [Internet] Brasília (DF): Ministério da Saúde, 2012. [citado 2020 May 21]. 320 p. Disponível em: Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/cadernos_atencao_basica_32_prenatal.pdf1
» https://bvsms.saude.gov.br/bvs/publicacoes/cadernos_atencao_basica_32_prenatal.pdf1
Centers for Disease Control and Prevention. Prevention of Perinatal Group B Streptococcal Disease. Revised Guidelines from CDC, 2010. MMWR. 2010;59(RR-10):1-32.
Hillier SL, Ferrieri P, Edwards MS, Ewell M, Ferris D, Fine P, et al. A Phase 2, randomized, control trial of Group B Streptococcus (GBS) type III capsular polysaccharide-tetanus toxoid (GBS III-TT) vaccine to prevent vaginal colonization with GBS III. Clin Infect Dis. 2019;68(12):2079-86.
Jones N, Oliver KA, Barry J, Harding RM, Bisharat N, Spratt BG, et al. Enhanced Invasiveness of Bovine-Derived Neonatal Sequence Type 17 Group B Streptococcus is Independent of Capsular Serotype. Clin Infect Dis . 2016;42(7):915-24.
Madhi SA, Cutland CL, Jose L, Koen A, Govender N, Wittke F et al. Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial. Lancet Infect Dis. 2016;16(8):923-34.
Madhi SA, Dangor Z. Prospects for preventing infant invasive GBS disease through maternal vaccination. Vaccine. 2017;35(35 Pt A):4457-60.
Madrid L, Seale AC, Kohli-Lynch M, Edmond KM, Lawn JE, Heath PT, et al. Infant Group B Streptococcal Disease Incidence and Serotypes Worldwide: Systematic Review and Meta-analysis. Clin Infect Dis . 2017;65(S2):S160-S172. https://doi 10.1093/cid/cix656.
» https://doi.org/10.1093/cid/cix656
Maeland JA, Afset JE, Ling RV, Radtke A. Survey of immunological features of the alpha-like proteins of Streptococcus agalactiae Clin Vaccine Immunol. 2015;22(2):153-9.
Murayama SY, Seki C, Sakata H, Sunaoshi K, Nakayama E, Iwata S et al. Capsular type and antibiotic resistance in Streptococcus agalactiae isolates from patients, ranging from newborns to the elderly, with invasive infections. Antimicrob Agents Chemother. 2009;53(6):2650-3.
Palmeiro JK, Dalla-Costa LM, Fracalanzza SEL, Botelho ACN, Nogueira KS, Scheffer MC, et al. Phenotypic and genotypic characterization of group B streptococcal isolates in Southern Brazil. J Clin Microbiol. 2010;48(12):4397-408.
Patras KA, Nizet V. Group B Streptococcal maternal colonization and neonatal disease: molecular mechanisms and preventative approaches. Front Pediatr. 2018;6:27.
Poyart C, Tazi A, Réglier-Poupet H, Billoët A, Tavares N, Raymond J, et al. Multiplex PCR assay for rapid and accurate capsular typing of group B streptococci. J Clin Microbiol . 2007;45(6):1985-8.
Russel NJ, Seale AC, O
Sullivan K, Bianchi- Jassir F, Gonzalez-Guarin J, et al. Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide: Systematic Review and Meta-analyses. Clin Infect Dis . 2017;65(S2):S100-S111.
Shabayek S, Spellerberg B. Group B Streptococcal colonization, molecular characteristics, and epidemiology. Front Microbiol. 2018;9:437.
Souza VC, Kegele FOC, Souza SR, Neves FPG, Paula GR, Barros RR. Antimicrobial susceptibility and genetic diversity of Streptococcus agalactiae recovered from newborns and pregnant women in Brazil. Scand J Infect Dis. 2013;45(10):780-5.
Verani JR, Schrag SJ. Group B streptococcal disease in infants: progress in prevention and continued challenges. Clin Perinatol. 2010;37(2):375-92.
Waight PA, Andrews NJ, Ladhani SN, Sheppard CL, Slack MPE, Miller E. Effect of the 13-valent pneumococcal conjugate vaccine on invasive pneumococcal disease in England and Wales 4 years after its introduction: an observational cohort study. Lancet Infect Dis . 2005;15(5):535-43.
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