The effect of lithium tetraborate as a novel cardioprotective agent after renal ischemia-reperfusion injury
DOI:
https://doi.org/10.1590/s2175-97902022e201052Keywords:
Ischaemia-reperfusion, remote organ damage, Boron compounds, cardioprotective agent, Lithium tetraborateAbstract
Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as an anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, we employed an in vivo rat model with kidney ischemia reperfusion injury to evaluate cardiac injury to clarify the mechanisms of lithium tetraborate. The evaluation of cardiac injury through kidney artery occlusion and reperfusion rat model indicated that lithium tetraborate could (1) reduce oxidative stress-induced endothelial dysfunction; (2) attenuate the inflammatory response of cardiac cells; and (3) alleviate the apoptosis and necrosis of myocytes. In summary, lithium tetraborate demonstrates significant therapeutic properties that contribute to the amelioration of cardiac damage, and it could be a promising candidate for future applications in myocardial dysfunction.
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Bahadoran H, Naghii MR, Mofid M, Asadi MH, Ahmadi K, Sarveazad A. Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat. Endocr Regul. 2016;50(4):194-206.
Baraldi O, Bianchi F, Menghi V, Angeletti A, Chiocchini ALC, Cappuccilli M, et al. An in vitro model of renal inflammation after ischemic oxidative stress injury: nephroprotective effects of a hyaluronan ester with butyric acid on mesangial cells. J Inflamm Res. 2017;10:135-42.
Charubala CS, Annalakshmi O, Jakathamani S, Sankaran MR, Venkatraman B, Jose MT. Studies on pelletized lithium magnesium borate TL material for eye lens dosimetry. J Radiol Prot. 2019;39(1):178-92.
Chistiakov DA, Shkurat TP, Melnichenko AA, Grechko AV, Orekhov AN. The role of mitochondrial dysfunction in cardiovascular disease: a brief review. Ann Med. 2018;50(2):121-7.
de Almeida AAC, Silva RO, Nicolau LAD, de Brito TV, de Sousa DP, dos Reis Barbosa AL, et al. Physio-pharmacological investigations about the anti-inflammatory and antinociceptive efficacy of (+)-limonene epoxide. Inflammation 2017;40(2):511-22.
Ding S, Liu D, Wang L, Wang G, Zhu Y. Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and regulating NLRP3 and apoptosis pathway. J Pharmacol Exp Ther. 2020;372(1):128-35.
D’Onofrio N, Servillo L, Balestrieri ML. SIRT1 and SIRT6 signaling pathways in cardiovascular disease protection. Antioxid Redox Signal. 2018;28(8):711-32.
Fernandes GFS, Denny WA, Dos Santos JL. Boron in drug design: Recent advances in the development of new therapeutic agents. Eur J Med Chem. 2019;179:791-804.
Galdos FX, Guo Y, Paige SL, VanDusen NJ, Wu SM, Pu WT. Cardiac regeneration: lessons from development. Circ Res. 2017;120(6):941-59.
Ghoreyshi M, Mahmoudabady M, Bafadam S, Niazmand S. The protective effects of pharmacologic postconditioning of hydroalcoholic extract of Nigella sativa on functional activities and oxidative stress ınjury during ıschemia- reperfusion in ısolated rat heart. Cardiovasc Toxicol. 2020;20(2):130-8.
Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation. 2003;108(16):1912-16.
Guo J, Zhang K, Ji Y, Jiang X, Zuo S. Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats. J Huazhong Univ Sci Technol Med Sci. 2008;28(3):281-3.
Ince S, Keles H, Erdogan M, Hazman O, Kucukkurt I. Protective effect of boric acid against carbon tetrachloride- induced hepatotoxicity in mice. Drug Chem Toxicol. 2012;35(3):285-92.
Ischia J, Bolton D, Patel O. Why is it worth testing the ability of zinc to protect against ischaemia reperfusion injury for human application. Metallomics. 2019;11(8):1330-43.
Jackaman C, Tomay F, Duong L, Razak NBA, Pixley FJ, Metharom P, et al. Aging and cancer: the role of macrophages and neutrophils. Ageing Res Rev. 2017;36:105-16.
Jung H, Choi EK, Baek SI, Cho C, Jin Y, Kwak KH, et al. The effect of nitric oxide on remote ıschemic preconditioning in renal ıschemia reperfusion ınjury in rats. Dose-Response. 2019;17(2):1-10.
Kar F, Hacioglu C, Senturk H, Donmez DB, Kanbak G. The role of oxidative stress, renal ınflammation, and apoptosis in post ıschemic reperfusion ınjury of kidney tissue: the protective effect of dose-dependent boric acid administration. Biol Trace Elem Res. 2020;195(1):150-8.
Khaliq H, Jing W, Ke X, Ke-Li Y, Peng-peng S, Cui L, et al. Boron affects the development of the kidney through modulation of apoptosis, antioxidant capacity, and Nrf2 pathway in the African ostrich chicks. Biol Trace Elem Res . 2018;186(1):226-37.
Kleinbongard P, Gedik N, Witting P, Freedman B, Klöcker N, Heusch G. Pleiotropic, heart rate-independent cardioprotection by ivabradine. Br J Pharmacol. 2015;172(17):4380-90.
Lan H, Su Y, Liu Y, Deng C, Wang J, Chen T, et al. Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway. Life Sci. 2019;228:35-46.
Li K, Lu X, Razanau I, Wu X, Hu T, Liu S, et al. The enhanced angiogenic responses to ionic dissolution products from a boron-incorporated calcium silicate coating. Mater Sci Eng C Mater Biol Appl. 2019;101:513-20.
Liu B, Qi W, Tian L, Li Z, Miao G, An W, et al. In vivo biodistribution and toxicity of highly soluble PEG-coated boron nitride in mice. Nanoscale Res Lett. 2015;10(1):478.
Liu X, Chen Z. The pathophysiological role of mitochondrial oxidative stress in lung diseases. J Transl Med. 2017;15(1):207.
Liu S, Wu XF, Zhang WZ, Sun YX, Cai SL. Remote postconditioning by brief renal ischemia and reperfusion reduces acute myocardial ischemia and reperfusion induced myocardial apoptosis in rabbits. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35(8):757-760.
Ma J, He W, Gao C, Yu R, Xue P, Niu Y. Glucosides of chaenomeles speciosa attenuate ischemia/reperfusion-induced brain injury by regulating NF-κB P65/TNF-α in mouse model. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2019;48(3):289-95.
Mattera R, Benvenuto M, Giganti MG, Tresoldi I, Pluchinotta FR, Bergante S, et al. Effects of polyphenols on oxidative stress-mediated injury in cardiomyocytes. Nutrients. 2017;9(5):523-66.
Menshikh A, Scarfe L, Delgado R, Finney C, Zhu Y, Yang H, et al. Capillary rarefaction is more closely associated with CKD progression after cisplatin, rhabdomyolysis, and ischemia reperfusion-induced AKI than renal fibrosis. Am J Physiol Renal Physiol. 2019;317(5):F1383-97.
Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, et al. Histones and neutrophil extracellular traps enhance tubular necrosis and remote organ injury in ischemic AKI. J Am Soc Nephrol. 2017;28(6):1753-68.
Romero-Aguilar KS, Arciniega-Martínez IM, Farfán-García ED, Campos-Rodríguez R, Reséndiz-Albor AA, Soriano-Ursúa MA. Effects of boron-containing compounds on immune responses: review and patenting trends. Expert Opin Ther Pat. 2019;29(5):339-51.
Ronco C, Haapio M, House AA, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol. 2008;52(19):1527-39.
Routray I, Ali S. Boron inhibits apoptosis in hyperapoptosis condition: Acts by stabilizing the mitochondrial membrane and inhibiting matrix remodeling. Biochim Biophys Acta Gen Subj. 2019;1863(1):144-52.
Shan Q, Li X, Zheng M, Lin X, Lu G, Su D, et al. Protective effects of dimethyl itaconate in mice acute cardiotoxicity induced by doxorubicin. Biochem Biophys Res Commun. 2019;517(3):538-44.
Shen WC, Chou YH, Huang HP, Sheen JF, Hung SC, Chen HF. Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction. Stem Cell Res Ther. 2018;9:344-56.
Studneva I, Serebryakova L, Veselova O, Pal’keeva M, Molokoedov A, Ovchinnikov M, et al. Galanin receptors activation modulates myocardial metabolic and antioxidant responses to ischaemia/reperfusion stress. Clin Exp Pharmacol Physiol. 2019;46(12):1174-82.
Tan Q, Yan X, Song L, Yi H, Li P, Sun G. Induction of mitochondrial dysfunction and oxidative damage by antibiotic drug doxycycline enhances the responsiveness of glioblastoma to chemotherapy. Med Sci Monit. 2017;23:4117- 25.
Wang TT, Shi MM, Liao XL, Li YQ, Yuan HX, Li Y, et al. Overexpression of inducible nitric oxide synthase in the diabetic heart compromises ischemic postconditioning. J Mol Cell Cardiol. 2019;129:144-53.
Xiao YD, Huang YY, Wang HX, Wu Y, Leng Y, Liu M, et al. Thioredoxin-interacting protein mediates NLRP3 inflammasome activation involved in the susceptibility to ischemic acute kidney injury in diabetes. Oxid Med Cell Longev. 2016;2016:1-7.
Türkoğlu S, Celik S, Keser S, Türkoğlu İ, Yılmaz Ö. The effect of Pistacia terebinthus extract on lipid peroxidation, glutathione, protein, and some enzyme activities in tissues of rats undergoing oxidative stress. Turk J Zool. 2017;41(1):82-8.
Yildirim S, Celikezen FC, Oto G, Sengul E, Bulduk M, Tasdemir M, et al. An investigation of protective effects of litium borate on blood and histopathological parameters in acute cadmium-induced rats. Biol Trace Elem Res . 2018;182(2):287-94.
Zhang LP, Jiang YC, Yu XF, Xu HL, Li M, Zhao XZ, et al. Ginsenoside Rg3 improves cardiac function after myocardial ischemia/reperfusion via attenuating apoptosis and inflammation. Evid Based Complement Alternat Med. 2016;2016:1-8.
Zhu Z, Zhong C, Xu T, Wang A, Peng Y, Xu T, et al. Effect of renal function status on the prognostic value of heart rate in acute ischemic stroke patients. Atherosclerosis. 2017;263:1-6.
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Atatürk Üniversitesi
Grant numbers FBA-2018-6954
