Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract

Authors

  • Matheus Gabriel de Oliveira
  • Guilherme Gomes Moreira Laboratório de Pesquisa, Desenvolvimento e Inovação de Bioprodutos, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0003-1162-6511
  • Andressa Tuane Santana Paz Laboratório de Pesquisa em Produtos Naturais, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0002-2754-7474
  • Thiago Levi Silva Oliveira Laboratório de Pesquisa em Produtos Naturais, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0003-3848-5261
  • Luís Antônio Dantas Silva Laboratório de Nanotecnologia Farmacêutica e Sistemas de Liberação de Fármacos, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0001-5328-237X
  • Edemilson Cardoso da Conceição Laboratório de Pesquisa, Desenvolvimento e Inovação de Bioprodutos, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0003-4113-2686
  • Leonardo Luiz Borges Escola de Ciências Médicas e da Vida, Pontifícia Universidade Católica de Goiás, Goiânia, Brasil Laboratório de Pesquisa, Desenvolvimento & Inovação de Produtos da Biodiversidade, Universidade Estadual de Goiás, Campus Central, Anápolis, Brasil http://orcid.org/0000-0003-2183-3944
  • Vinicius Barreto da Silva Escola de Ciências Médicas e da Vida, Pontifícia Universidade Católica de Goiás, Goiânia, Brasil http://orcid.org/0000-0002-5066-7431
  • José Realino de Paula Laboratório de Pesquisa em Produtos Naturais, Universidade Federal de Goiás, Goiânia, Brasil http://orcid.org/0000-0002-4424-7692

DOI:

https://doi.org/10.1590/s2175-97902023e21211

Keywords:

Anxiety, Medicinal plants, Phytotherapy, Powder properties, Spray drying

Abstract

Hydrocotyle umbellata L., Araliaceae, is a species that is recommended in Ayurvedic medicine for its effects on the central nervous system, such as anxiolytic and memory-stimulant effects. Despite the medicinal potential of this species, its phytopharmaceutical and technological potential to produce standardized extracts has not been investigated. This study analyzes the influence of spray drying parameters on the contents of the chemical markers (total phenolic, total flavonoid, and hibalactone) and the functional properties of H. umbellata extract. The optimization of drying conditions was performed using a central composite design combined with response surface methodology and desirability function approach. The mathematical models fitted to experimental data indicated that all the evaluated drying parameters significantly influenced the chemical contents. The optimal conditions were: inlet temperature of 120 °C, feed flow rate of 4 mL min-1, and colloidal silicon dioxide:maltodextrin ratio of 16%:4%. Under these conditions, the powder samples had spherical particles and desirable physicochemical and functional properties, such as low water activity and moisture content, good product recovery, reconstitution, and flowability. Thus, spray drying might be a promising technique for processing standardized H. umbellata extracts.

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Published

2023-05-26

Issue

Vol. 59 (2023)

Section

Original Article

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How to Cite

Process optimization of physicochemical properties of spray-dried Hydrocotyle umbellata L. extract. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e21211. https://doi.org/10.1590/s2175-97902023e21211