Fotobiomodulación láser en la respuesta inflamatoria aguda en lesión del tendón calcáneo en ratones expuestos a humo de cigarrillo
DOI:
https://doi.org/10.1590/1809-2950/18032726022019Palabras clave:
Terapia Láser de Baja Intensidad, Tendón del Calcáneo, Tendinopatía, InflamaciónResumen
La nicotina retarda el proceso de cicatrización y eleva los niveles de la enzima mieloperoxidasa (MPO), que tiene un papel fundamental en la producción de especies reactivas de oxígeno durante el proceso inflamatorio. La fotobiomodulación con láser (FBM) es uno de los agentes electrofísicos más utilizados en el tratamiento del tendón calcáneo, sin embargo sus efectos sobre la actividad de la MPO carecen de mayor elucidación. Este estudio objetivó evaluar los efectos de la FBM sobre la actividad de la MPO después de lesión del tendón calcáneo en ratones expuestos al humo de cigarrillo. Se utilizaron 34 ratones Wistar, machos, con 90 días de vida. Después de 14 días de exposición al humo de cigarrillo, los animales fueron divididos en tres grupos experimentales: grupo de control (GC, n=12), no sometido a la lesión o tratamiento; grupo sham (GSh, n=10), sometido a la lesión parcial del tendón calcáneo y a la simulación de la FBM láser; y el grupo FBM láser (GFBM, n=12), sometido a la lesión parcial del tendón calcáneo y tratado con FBM láser, en el primer minuto después de la lesión. La FBM disminuyó los niveles de actividad de MPO en el GFBM en comparación con el GSh (GC: 1,38±0,69 pg/ml; GSh: 3,78±1,09pg/ml; GFBM: 2,58±0,93pg/ml, p<0,005). Se concluye que la FBM láser aplicada inmediatamente después de la lesión del tendón calcáneo atenúa la actividad inflamatoria aguda en ratones expuestos al humo de cigarrillo.
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Derechos de autor 2019 Naira Helena Bohrer Scherer, Antonio Marcos Vargas da Silva, Jessié Gutierres, Carolina Fantinel Veloso, Carlos Eduardo Pinfildi, Rafael Corrêa Gobbato
Esta obra está bajo una licencia internacional Creative Commons Atribución-CompartirIgual 4.0.
