Oral delivery systems for peptides and proteins: III. Application to insulin
DOI:
https://doi.org/10.1590/S1516-93322003000100003Keywords:
Absorption enhancer, Microencapsulation, Natural polymers, Oral insulin, Protease inhibitorsAbstract
Insulin is an important therapeutic protein, generally administered subcutaneously due to the obstacles of oral delivery. A number of different methods have been explored to improve the low oral bioavailability of insulin, particularly in the last decade, namely protease inhibitors, absorption enhancers, chemical modification and the formulation approach which includes particulate systems, emulsions, targeting delivery systems and bioadhesive systems. Although an effective formulation for oral insulin delivery remains to be achieved, the results are encouraging. Microencapsulation has proven to be a promising method of choice, especially when using natural polymers.Downloads
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Published
2003-03-01
Issue
Section
Original Papers
How to Cite
Oral delivery systems for peptides and proteins: III. Application to insulin. (2003). Revista Brasileira De Ciências Farmacêuticas, 39(1), 21-40. https://doi.org/10.1590/S1516-93322003000100003