Melittin: the use of the main component of bee venom in the fight against lung tumor cell lines
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i6e-200516Keywords:
Antineoplastics, Peptides, NanoparticlesAbstract
Introduction: Melittin is a peptide formed by 26 amino acids and the main compound of the venom produced by honeybees. Preclinical studies demonstrated an antineoplastic capacity of the compound, evidencing its effect on cancer cell lines. Lung cancer is the deadliest cancer in the world, nine out of ten cases of this disease are related to smoking history. Late diagnosis, often due to lack of clinical symptoms, directly compromises treatment and prognosis, generating a low survival rate. In this sense, melittin appears as a therapeutic approach in lung cancer treatment. Objective: Carry out an integrative review of the literature on research published in the last five years about the effect of melittin on human lung tumor cell lines. Results: 15 publications were found, 10 were excluded because they didn’t respond directly to the proposed objective or because they were duplicate articles, and five were chosen to compose this review. Discussion: Melittin proved to be efficient in controlling lung tumor cell lines, corroborating the results already reported in other tumor cell lines. Conclusion: The use of melittin is a potential approach in the treatment of lung cancer.
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