Efeitos cardiovasculares de linalol livre ou complexado à β-ciclodextrina: um foco para ação anti-hipertensiva
DOI:
https://doi.org/10.11606/issn.1679-9836.v102i6e-203574Palavras-chave:
Doenças Cardiovasculares, Linalol, Ciclodextrina, Hipertensão arterial, Beta- CiclodextrinasResumo
Introdução: O monoterpeno linalol (LIN) apresenta várias atividades farmacológicas, inclusive como anti-hipertensivo, porém, apresenta problemas de solubilidade devido ao seu caráter lipofílico. Dessa forma, estratégias de estabilização e melhoria de parâmetros farmacocinéticos e farmacodinâmicos vem sendo estudadas, como a formação de complexos de inclusão com ciclodextrinas (CDs). Objetivo: O objetivo desta revisão é reunir informações sobre os efeitos cardiovasculares do LIN e avaliar a possibilidade do uso de CDs para melhorar as propriedades biológicas do LIN. Metodologia: Esta revisão de literatura abrangeu artigos no período entre 1998 e 2022, coletadas nas bases de dados PUBMED, SciELO, LILACS e MEDLINE. Resultados: Em ratos normotensos, o LIN induziu hipotensão associada à taquicardia, enquanto em ratos hipertensos, reduziu a pressão arterial sem alterar a frequência cardíaca. O LIN tem ação direta sobre a vasculatura promovendo relaxamento vascular e melhora da função cardíaca. Interessantemente, a complexação de LIN com β-CDs melhorou a atividade anti-hipertensiva do monoterpeno. Conclusão: Foi evidenciado nesta revisão o potencial farmacológico do LIN como agente hipotensor, relaxante vascular e anti-hipertensivo. Além disso, há evidências que é possível melhorar o efeito anti-hipertensivo do LIN com a utilização de sistemas de inclusão com CDs, porém, estudos adicionais sobre este tema deverão ser realizados.
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