Benzodiazepine dependence and genetic factors: a literature review
DOI:
https://doi.org/10.11606/issn.1679-9836.v102iespe-203848Keywords:
Benzodiazepines, Genetic Research, Substance-Related DisordersAbstract
Benzodiazepines (BZDs) are psychotropic drugs, central nervous system (CNS) depressants, used worldwide in clinical practice. Its exacerbated consumption and addiction has become a public health issue. The etiology of BZD dependence occurs due to several factors, both genetic and non-genetic. The objective of this review is to compile the genetic factors associated with the dependence mechanisms of BZDs. The genetic mechanisms of BZDs involve interaction with glutamate receptors and GABA modulation, reducing brain activation and memory creation. The BAIAP 3 genotype is the first marker of genetic risk of anxiety and abuse of BZDs. Another mechanism is the polymorphisms of cytochrome P450 monooxygenases enzymes (CYP450). The increase in the chronic use of BZDs has a major impact on public health. Thus, it is essential to analyze the genetic factors that increase dependence, aiming at an individualized therapy and the reduction of this problem.
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Copyright (c) 2023 Beatriz Milene de Oliveira Camargo, Maria Júlia da Gama Fortunato Ziliani, Ana Luiza Alvarenga, Bianca Calciolari, Rafael Shoiti Nagao, Luis Felipe Gomes Michelin, Aline Alexandrino Antunes, Daniel Moreno Garcia
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