Production of pellets by pharmaceutical extrusion and spheronisation. Part II: physical characterisation of pellets

Authors

  • Helton Max Massaranduba Santos Universidade de Coimbra; Faculdade de Farmácia; Centro de Estudos Farmacêuticos
  • Francisco José Batista Veiga Universidade de Coimbra; Faculdade de Farmácia; Centro de Estudos Farmacêuticos
  • Eugênica Maria Soares Tavares de Pina Universidade de Coimbra; Faculdade de Farmácia; Centro de Estudos Farmacêuticos
  • João José Martins Simões de Sousa Universidade de Coimbra; Faculdade de Farmácia; Centro de Estudos Farmacêuticos

DOI:

https://doi.org/10.1590/S1516-93322006000300002

Keywords:

Physical characterisation, Pellets, Pelletisation, Sphere

Abstract

The pelletisation process described in Part I consists of the wet agglomeration of fine powders of a drug substance and excipients into spherical units referred as pellets. Pellets differ from granules in terms of the production process and the physical characteristics. The current work, the second part of a series of two, intends to describe and revise the literature of the evaluation and characterisation of active drug pellets regarding the needs of postproduction of the units namely, film coating, capsule filling, compression, handling, storing and shiping.

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Published

2006-09-01

Issue

Vol. 42 No. 3 (2006)

Section

Revisões

How to Cite

Production of pellets by pharmaceutical extrusion and spheronisation. Part II: physical characterisation of pellets. (2006). Revista Brasileira De Ciências Farmacêuticas, 42(3), 309-318. https://doi.org/10.1590/S1516-93322006000300002