Assessment of quality of life in patients with inflammatory bowel disease
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2022.188023Keywords:
Ulcerative rectocolitis, Crohn’s disease, Quality of life, DepressionAbstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, occurring mainly in the young, socioeconomically active age group. Both the recurrent-remitting course of symptoms and the chronicity of the disease impact patients’ quality of life (QoL). Objective: determine the contributing factors associated
with QoL in IBD patients in a tertiary service. Methods: a cross-sectional study of patients seen at the IBD outpatient clinic of the Federal University of Pelotas from January to November 2020, with clinical and laboratory data collection. Disease assessment was performed using Crohn’s Disease Activity Index for Crohn’s disease and Mayo score for ulcerative colitis and quality of life through the Inflammatory Bowel Disease Questionnaire (IBDQ). Results: the presence of a history of depression resulted in a significant impact on the overall QoL (p = 0.005) and
mainly in the systemic symptoms (p = 0.04), social (p <0.001), and emotional (p = 0.008) domains. Regarding disease activity, statistical significance was evidenced in the intestinal symptoms domain (p <0.001) and overall QoL (p <0.001). Conclusion: a history of psychiatric illness and IBD disease activity were predictors of poorer QoL assessed by the IBDQ.
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References
Spehlmann ME, Begun AZ, Burghardt J, Lepage P, Raedler A, Schreiber S. Epidemiology of inflammatory bowel disease in a German twin cohort: Results of a nationwide study. Inflamm Bowel Dis. 2008;
Restall GJ, Simms AM, Walker JR, Graff LA, Sexton KA, Rogala L, et al. Understanding Work Experiences of People with Inflammatory Bowel Disease. Inflamm Bowel Dis. 2016;
Eckert KG, Abbasi-Neureither I, Köppel M, Huber G. Structured physical activity interventions as a complementary therapy for patients with inflammatory bowel disease - A scoping review and practical implications. BMC Gastroenterol. 2019;
Carroll MW, Kuenzig ME, Mack DR, Otley AR, Griffiths AM, Kaplan GG, et al. The Impact of Inflammatory Bowel Disease in Canada 2018: Children and Adolescents with IBD. J Can Assoc Gastroenterol. 2019;
Knowles SR, Graff LA, Wilding H, Hewitt C, Keefer L, Mikocka-Walus A. Quality of Life in Inflammatory Bowel Disease: A Systematic Review and Meta-analyses - Part i. Inflammatory Bowel Diseases. 2018.
Williet N, Sarter H, Gower-Rousseau C, Adrianjafy C, Olympie A, Buisson A, et al. Patient-reported Outcomes in a French Nationwide Survey of Inflammatory Bowel Disease Patients. J Crohns Colitis. 2017;
Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, et al. A New Measure of Health Status for Clinical Trials in Inflammatory Bowel Disease. Gastroenterology. 1989;
Hashimoto H, Green J, Iwao Y, Sakurai T, Hibi T, Fukuhara S. Reliabilty, validity, and responsiveness of the Japanese version of the Inflammatory Bowel Disease Questionnaire. J Gastroenterol. 2003;
Pontes RMA, Miszputen SJ, Ferreira-Filho OF, Miranda C, Ferraz MB. Qualidade de vida em pacientes portadores de doença inflamatória intestinal: tradução para o português e validação do questionário “Inflammatory Bowel Disease Questionnaire” (IBDQ). Arq Gastroenterol. 2004;
Haapamäki J, Heikkinen E, Sipponen T, Roine RP, Arkkila P. The impact of an adaptation course on health-related quality of life and functional capacity of patients with inflammatory bowel disease. Scand J Gastroenterol. 2018;
Velonias G, Conway G, Andrews E, Garber JJ, Khalili H, Yajnik V, et al. Older Age- and Health-related Quality of Life in Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2017;
Zhou Y, Ren W, Irvine EJ, Yang D. Assessing health-related quality of life in patients with inflammatory bowel disease in Zhejiang, China. J Clin Nurs. 2010;
Gibson PR, Weston AR, Shann A, Florin THJ, Lawrance IC, MacRae FA, et al. Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn’s disease. J Gastroenterol Hepatol. 2007;
Hauser G, Tkalcić M, Stimac D, Milić S, Sincić BM. Gender related differences in quality of life and affective status in patients with inflammatory bowel disease. Coll Antropol. 2011;
Vivan TK, Santos BM, dos Santos CHM. Quality of life of patients with inflammatory bowel disease. J Coloproctology. 2017;
Kiran RP, Delaney CP, Senagore AJ, O’Brien-Ermlich B, Mascha E, Thornton J, et al. Prospective assessment of Cleveland Global Quality of Life (CGQL) as a novel marker of quality of life and disease activity in Crohn’s disease. Am J Gastroenterol. 2003;
Bastida G, Beltrán B. Ulcerative colitis in smokers, non-smokers and ex-smokers. World J Gastroenterol. 2011;
Lunney PC, Kariyawasam VC, Wang RR, Middleton KL, Huang T, Selinger CP, et al. Smoking prevalence and its influence on disease course and surgery in Crohn’s disease and ulcerative colitis. Aliment Pharmacol Ther. 2015;
van der Heide F, Dijkstra A, Weersma RK, Albersnagel FA, van der Logt EMJ, Faber KN, et al. Effects of active and passive smoking on disease course of Crohn’s disease and ulcerative colitis. Inflamm Bowel Dis. 2009;
Nurmi E, Haapamäki J, Paavilainen E, Rantanen A, Hillilä M, Arkkila P. The burden of inflammatory bowel disease on health care utilization and quality of life. Scand J Gastroenterol. 2013;
Magalhães J, Castro FD de, Carvalho PB, Moreira MJ, Cotter J. Quality of life in patients with inflammatory bowel disease: importance of clinical, demographic and psychosocial factors. Arq Gastroenterol. 2014;
Ho PYM, Hu W, Lee YY, Gao C, Tan YZ, Cheen HH, et al. Health-related quality of life of patients with inflammatory bowel disease in Singapore. Intest Res. 2019;
Murdoch TB, O’Donnell S, Silverberg MS, Panaccione R. Biomarkers as potential treatment targets in inflammatory bowel disease: A systematic review. Can J of Gastroenterol Hepatol. 2015.
Jones J, Loftus E V., Panaccione R, Chen LS, Peterson S, Mcconnell J, et al. Relationships Between Disease Activity and Serum and Fecal Biomarkers in Patients With Crohn’s Disease. Clin Gastroenterol Hepatol. 2008;
Anderson A, Click B, Ramos-Rivers C, Koutroubakis IE, Hashash JG, Dunn MA, et al. The association between sustained poor quality of life and future opioid use in inflammatory bowel disease. Inflamm Bowel Dis. 2018;
Byrne G, Rosenfeld G, Leung Y, Qian H, Raudzus J, Nunez C, et al. Prevalence of anxiety and depression in patients with inflammatory bowel disease. Can J Gastroenterol Hepatol. 2017;
Neuendorf R, Harding A, Stello N, Hanes D, Wahbeh H. Depression and anxiety in patients with Inflammatory Bowel Disease: A systematic review. J Psychosom Res. 2016.
Stapersma L, van den Brink G, van der Ende J, Bodelier AG, van Wering HM, Hurkmans PCWM, et al. Illness Perceptions and Depression Are Associated with Health-Related Quality of Life in Youth with Inflammatory Bowel Disease. Int J Behav Med. 2019;
Tomazoni EI, Benvegnú DM. Symptoms of anxiety and depression, and quality of life of patients with Crohn’s disease. Arq Gastroenterol. 2018;
Gracie DJ, Irvine AJ, Sood R, Mikocka-Walus A, Hamlin PJ, Ford AC. Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2017;
Jarasvaraparn C, Zlomke K, Vann NC, Wang B, Crissinger KD, Gremse DA. The Relationship between Sleep Disturbance, Quality of Life and Psychosocial Functioning in Pediatric Patients with Inflammatory Bowel Disease. Ann Gastroenterol Dig Disord. 2018;
Almeida RS de, Lisboa ACR, Moura AR. Quality of life of patients with inflammatory bowel disease using immunobiological therapy. J Coloproctology. 2019;
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Copyright (c) 2022 Ives Alexandre Yutani Koseki, João Hélio Alves Marciano Neto, Djeison Mikael Campanher; Simoni Euzébio Nunes; Daniel Brito de Araujo, Elza Cristina Miranda da Cunha Bueno
This work is licensed under a Creative Commons Attribution 4.0 International License.
