Lead and anemia

Abstract

The plumbism is a public health problem, affecting the development the children. The hematologic system is a target important from lead poisoning, engaging the heme synthesis causing anemia. The effects above the aminolevulinate acid dehidrathase (ALAD) are very marking causing the accumulation aminolevulinic acid (ALA) and the increase of acid aminobutyric (GABA) in the nervous system central. The exacerbate lead toxicity demonstrated affect also the synthesis the globulins chains the one to contributory about to the development from anemia. The anemia isn’t a manifestation precocious of the plumbism, being clear when the levels of lead elevated for prolonged periods. The anemia generally is hypochromic normocytic, the microcytosis may be commonly observed, with presence of basophilic stippling in the erythocytes. Recently, was observed greater susceptibility the plumbism in the children with iron deficiency, being suggested by what the iron is capable of competed with the lead, inhibiting the binding with the transport protein DMT1 Divalent Metal Transporter 1). In the co-existence of iron deficiency and lead poisoning, the anemia is very severe, with accented degree of microcytosis and hypochromia, being recommended iron supplementation to children with risk of lead poisoning.