Effect of aqueous extract of Cordyline Dracaenóides Kunth in wound healing of skin lesions
DOI:
https://doi.org/10.11606/issn.2176-7262.v52i4p267-275Keywords:
Wound Healing, Collagen, PlantAbstract
Method of study: This is an experimental, randomized study. Introduction: The healing process is a dynamic set of important tissue changes involving inflammation and chemotaxis. Cordyline Dracaenoides Kunth, popularly known as Uvarana, is a plant that contributes to the healing process. Objective: In this context, this work aimed to verify the effects of the aqueous extract of Uvarana on the healing process. Method: The sample consisted of 42 Rattus norvegicus, Wistar rats divided into four experimental groups: Negative Control Group, Positive Control Group, Uvarana Group, and Fármaco Group, subdivided in 3 and 7 days. The animals were anesthetized with 80 mg/kg Ketamine and 15 mg/kg Xylazine and then placed in a ventral decubitus position on a surgical plank, after which a dorsal region tricotomy was performed and with a scalpel blade was made a 10mm incision. After the incision, wound closure was performed with nylon thread number 5.0. Results: It was observed that in the group in which the aqueous extract of Uvarana was applied, there was a regeneration of the epidermis with presence of crust, the dermal tissue presented inflammatory cells, the hypodermis had intense inflammation, the epidermis became thicker on the seventh day and the dermis presented regenerative collagen cells and scar closure. Conclusion: Based on this study, it can be concluded that the aqueous extract of Uvarana is a very effective method in the treatment of cutaneous lesions and has the capacity to accelerate the healing process.
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