Hematuria leading to the diagnosis of two singular conditions in clinical practice - renal nutcracker syndrome and sickle cell trait

a case report

Authors

DOI:

https://doi.org/10.11606/issn.2176-7262.v53i2p189-193

Keywords:

Hematuria, Renal Nutcracker Syndrome, Sickle Cell Trait

Abstract

Hematuria is defined as the finding more than two red blood cells per field of analysis in the microscopic analysis of the urine collected by the medium jet. In its macroscopic form, it is characterized by its typical coloration (reddish or brown), accompanied by the presence of more than 106 red cells/ml in urinary sediment. It is a condition that needs investigation and it presents itself sometimes with imprecise definition, but with vast differential diagnosis. Among the possible etiologies, there is the presence of the sickle cell trait, apparently underdiagnosed, and the renal nutcracker syndrome, a rarer possibility. In the case reported below, these two findings were diagnosed simultaneously, following an investigation of the first episode of macroscopic hematuria in a young and previously healthy woman. In order to draw attention to the simultaneous presence of two unusual causes of hematuria in the same patient, we report the following case.

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References

Abreu PF, Requião-Moura LR, Sesso R. Avaliação diagnóstica de hematúria. J Bras Nefrol. 2007; 29:158-63.

Richards KA, Ruiz VL, Murphy DR, Downs TM, Abel EJ, Jarrard DF et al. Diagnostic evaluation of patients presenting with hematuria: an electronic health record-based study. Urol Oncol. 2018; 36:e19–88.

Nørgaard M, Veres K, Ording AG, Djurhuus JC, Jensen JB, Sørensen HT. Evaluation of Hospital-Based Hematuria Diagnosis and Subsequent Cancer Risk Among Adults in Denmark. JAMA Netw Open. 2018; 1(7):e184909.

Tan WS, Feber A, Sarpong R, Khetrapal P, Rodney S, Jalil R et al. Who Should Be Investigated for Haematuria? Results of a Contemporary Prospective Observational Study of 3556 Patients. Eur Urol.2018; 74:10-14.

Marques GL, Carvalho JG, Nascimento MM, Marks SG, Olbertz LG. Nutcracker syndrome as a cause of recurrent hematuria in a young woman: a case report. J Bras Nefrol. 2012; 34:195-8.

Macedo GL, Santos MA, Sarris AB, Gomes RZ. Diagnóstico e tratamento da síndrome de quebra-nozes (nutcracker): revisão dos últimos 10 anos. J. vasc. bras. 2018; 17(3): 220-228.

Ananthan K, Onida S, Davies AH. Nutcracker syndrome: an update on current diagnostic criteria and management guidelines. Eur J Vasc Endovasc Surg. 2017; 53:886–894.

Zhang H, Zhang N, Li M, et al. Treatment of six cases of left renal nutcracker phenomenon: surgery and endografting. Chin Med J (Engl) 2003;116:1782-4.

Key NS, Derebail VK. Sickle-cell trait: novel clinical significance. Hematology Am Soc Hematol Educ Program. 2010; 2010:418–422.

Lervolino LG, Baldin PE, Picado SM, Calil KB, Viel AA, Campos LA. Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies. Rev. Bras. Hematol. Hemoter. 2011; 33, 49–54.

Silva WS, de Oliveira RF, Ribeiro SB, da Silva IB, de Araújo EM, Baptista AF. Screening for structural hemoglobin variants in Bahia, Brazil. Int J Environ Res Publ Health. 2016; 13:225.

Kiryluk K, Jadoon A, Gupta M, Radhakrishnan J. Sickle celltrait and gross hematuria. Kidney Int. 2007; 71(7):706–710.

Joncour AL, Mesnard L, Hertig A, Robert T. Red urine, updated for the nephrologist: a case report. BMC Nephrology. 2018; 19:133.

Ahmad A, McElwee SK, Kraemer RR. Nutcracker syndrome and sickle cell trait: a perfect storm for hematuria. J Gen Intern Med. 2017; 32 (5): 585 – 588.

Published

2020-08-07

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Section

Relato de Caso

How to Cite

1.
Gomes OV, Rodrigues M de S, Santana LF e, Souza CEO, Damasceno LP, Vieira RV. Hematuria leading to the diagnosis of two singular conditions in clinical practice - renal nutcracker syndrome and sickle cell trait: a case report. Medicina (Ribeirão Preto) [Internet]. 2020 Aug. 7 [cited 2024 May 18];53(2):189-93. Available from: https://www.periodicos.usp.br/rmrp/article/view/162263