Clinical and metabolic profile of HIV-positive patients with lipodistrophy

Abstract

Study Design: Descriptive Study. Objective: To evaluate the clinical and metabolic profile of HIV-seropositive patients on HAART with adiagnosis of associated lipodystrophy. Methods: We analyzed data computed in a protocol attached tothe records of patients treated at the University Hospital of the Medical School of Ribeirão Preto. Results:69.7% of the participants were male. Mean ± standard deviation body mass index was 24.7 ± 3.6 kg/m2and 26.7 ± 5.98 kg/m2, and average weight 72.78 ± 12.7 kg and 65.94 ± 15.4 kg for males and females,respectively. The percentage of lean mass was greater in men (p = 0.0008) and body fat was greater inwomen (p = 0.0006). Median total cholesterol was 235 mg/dl and median triglycerides were 387 mg/dl.Fifty percent of the patients had abdominal lipohypertrophy, 27.9% facial lipoatrophy, and 12.5% cervicallipohypertrophy. Conclusion: Clinical and metabolic changes were detected, which represent additionalrisk factors for the occurrence of coronary diseases in these patients.