Relationship between the renin-angiotensin system and cardiovascular responses promoted by exercise training

Abstract

Introduction and Objective: The renin angiotensin system (RAS) has an important function in the homeostasis of cardiovascular system, and the activation of the classical pathway results in the formation of angiotensin II which lead to increased blood pressure (BP). Whereas exercice interferes in cardiovascular responses to angiotensin II and consequently reduces the BP. Whereas exercice interferes in cardiovascular responses, this study aimed to review the literature regarding the possible relationship of physical training with the RAS.

Methods: The work was divided into sessions of studies involving animals and studies involving humans. Searches were performed in Medline database, and the main criteria were samples with animals ou humans and articles published in English. After applied the inclusion and exclusion criteria, we selected 12 articles involving animals and 8 involving humans.

Results: The studies involving animals and humans have shown that there is a relationship between physical training and RAS, and  cardiovascular responses observed after exercice may have some relationship with the RAS. Furthermore, studies in humans have shown that polymorphisms in some genes of the RAS may also be crucial to the cardiovascular responses found after exercice. 

Conclusion: Given the recent research linking cardiovascular responses after exercice with the SRA, this relationship seems to be important to consider the mechanism responsible for promoting certain cardiovascular responses after exercise, such as hypotension.